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The front of a 3 oz. bottle of ProgestaKey, a natural progesterone body crème that is derived from wild yam.
The front of a 3 oz. bottle of ProgestaKey, a natural progesterone body crème that is derived from wild yam.

"I got my life back! For months my cycles were trending more and more debilitating. My first cycle utilizing ProgestaKey, every symptom subsided. So grateful!!"
– Shelby H.

 Verified buyer

ProgestaKey

all-natural topical progesterone cream from wild yam

The front of a 3 oz. bottle of ProgestaKey, a natural progesterone body crème that is derived from wild yam.
The front of a 3 oz. bottle of ProgestaKey, a natural progesterone body crème that is derived from wild yam.

Balance hormones naturally and easily with ProgestaKey—our gentle, bioidentical progesterone cream designed to support women at every stage of life.

• HORMONAL HARMONY – Helps regulate cycles, ease perimenopausal and menopausal symptoms, and restore balance when progesterone is low.

• BETTER SLEEP & MOOD – Encourages deeper sleep, reduces nighttime waking from hot flashes and night sweats, and helps calm anxiety and irritability.

• VITALITY & DRIVE – Boosts libido, energy, and overall well-being while making it easier to manage hormonal weight gain.

Quantity

Highlights

ProgestaKey is a bioidentical progesterone cream derived from wild yam, designed to support women experiencing hormonal fluctuations. Each pump provides 20 mg of USP progesterone, a dosage aligned with the body's natural hormone levels for effective and gentle support.


Progesterone levels often decline in the mid-30s and beyond, leading to symptoms such as hot flashes, mood swings, and sleep disturbances. By restoring natural progesterone levels, ProgestaKey helps alleviate these symptoms while promoting balance — without the use of synthetic hormones or petrochemicals.

How to Use

One full press of the pump will dispense the recommended 20 mg of natural progesterone. Apply to face, hands, chest, abdomen, inner arms or thighs. Rotate application area often to target all receptor sites.


Menstruating Women: Apply once or twice a day starting on the 12th day after the first day of menstrual flow through the 26th day.


Perimenopausal Women: Apply once or twice a day starting on the 7th day after the first day of menstrual flow through the 27th day.


Menopausal Women: Apply once or twice a day for a maximum of 25 consecutive days. Resume after a five-day break.


If using ProgestaKey with birth control, it is recommended for use only once every 3 days during the last 2 weeks of your cycle. Consult your health care practitioner for specific instructions.


May not be appropriate for pregnant and/or nursing women, or if you have a serious medical condition. Consult a health care professional before use.


Application is intended for external cosmetic use.

Product Facts

Form: Cream

Size: 3 oz (85 grams) (approx. 30 pumps per bottle)

One full press of the pump will dispense the recommended 20 mg of natural progesterone.

Not tested on animals. GMO-free. Made in USA.


Note: Prescription required for shipment to Canada.

Free Shipping Over $99

90 Day Returns

Secure Online Payment

Natural Support for Hormonal Harmony​

Improves Menstrual & Menopausal Symptoms
Helps reduce common menstrual and menopausal discomforts like hot flashes, night sweats, and mood fluctuations by restoring progesterone balance.​

Promotes Emotional Balance
Supports mood stability and reduces feelings of anxiety and irritability associated with hormonal changes.

Supports Restful Sleep
Aids in achieving better sleep quality by addressing hormonal imbalances that disrupt sleep patterns.​

Enhances Vitality and Metabolic Health
Supports healthy metabolic function to make weight management and energy balance easier, while also restoring sex drive and improving libido.

Restore Balance with Bioidentical Progesterone

A deficiency in progesterone can lead to a variety of unpleasant symptoms including mood swings, anxiety, depression, fatigue, insomnia, low libido, irregular menstrual cycles, and even difficulty with weight control. Many women experience these symptoms without realizing that declining progesterone levels may be the root cause.

Supporting healthy progesterone levels is key to promoting emotional stability, restful sleep, balanced cycles, and a calm mind. Proper progesterone also helps balance estrogen dominance, supports bone health, and aids in maintaining a healthy metabolism — making it an essential hormone for women's overall well-being throughout perimenopause, menopause, and beyond.

  • Key Ingredients

  • Full List of Ingredients

Natural Progesterone

This bioidentical form of progesterone, derived from wild yam, helps restore hormonal balance by supplementing the body’s natural progesterone levels. It plays a key role in easing symptoms of estrogen dominance, such as mood swings, weight gain, and irregular cycles.


Aloe Vera

Known for its soothing and skin-nourishing properties, aloe vera serves as a gentle base for ProgestaKey. It enhances absorption and provides a calming effect on the skin.


Vitamin E

A powerful antioxidant that supports skin health and stability of the formula. Vitamin E also promotes circulation and helps maintain hormone function.


MSM (Methylsulfonylmethane)

A natural sulfur compound that enhances skin permeability and absorption. MSM also supports connective tissue health and reduces inflammation.


Yarrow

A traditional herb with natural balancing properties, yarrow is included for its support in easing menstrual discomfort and encouraging hormonal equilibrium.


Evening Primrose Oil

Rich in gamma-linolenic acid (GLA), this oil supports hormone regulation and skin hydration. It’s especially helpful for breast tenderness and PMS symptoms.


Lavender

Added for its calming and soothing properties, lavender helps reduce stress and promotes emotional well-being during hormonal fluctuations.

Purified Water, Aloe Vera Gel, Caprylic/Capric Triglycerides, Natural Progesterone USP, Evening Primrose Oil, Vitamin E Acetate, MSM (Methyl Sulfonylmethane), Isostearic Acid, Yarrow Extract, Cranberry Extract, Glyceryl Stearate, Shea Butter, Lecithin, Glycerine USP, Lavender Essential Oil, Vanilla Extract, Allontoin, Sorbic Acid, and Grapeseed Extract.

Questions? We've Got Answers!

Can I use this with other HRT?

Yes, though it may be a good idea to evaluate your hormone levels with a Salivary Hormone Test, or consult your health care practitioner before use. Also, if using hormonal contraceptives, please use back up method of birth control.

Do I have to use this forever?

Progesterone is important for many aspects of health in women of all ages –– from balanced monthly cycles and mood swings to relieving hot flashes and night sweats and supporting healthy bones. You may use ProgestaKey long term, or just as long as you want to help manage symptoms.

My cycle is irregular. How do I decide when to start and stop ProgestaKey?

It's common for a woman's cycle to be as short as 20 days and as long as 40. Day 1 of your cycle is considered the first day of menstruation. The basic instructions for menstruating women advise using the creme from day 12 to 26. If your menses begins before day 26, simply stop using the creme when it begins, and resume again on day 12. If your menses is still happening by day 12, still begin using the creme as scheduled. If you experience spotting, stick to the regular schedule. If the spotting is so prevalent that you can't discern your true menses, simply use the creme for two weeks each month and keep consistent to that schedule.

I've had a hysterectomy. How should I use ProgestaKey?

If you've had a hysterectomy, please follow the directions for menopausal women, by applying the creme for 25 consecutive days and then taking a 5 day break.

I want to do the Salivary Hormone Test. Can I still use ProgestaKey?

To achieve an accurate reading, we recommend abstaining from the creme for at least 3-5 days prior to collecting your saliva sample. Menstruating women should collect their saliva on days 19, 20, or 21 of their cycle, so consider skipping ProgestaKey all together that cycle. Menopausal women can collect their saliva any day of the month, so aim to do so on the final day of the 5 day break from ProgestaKey.

Our Customers Say It Best

"ProgestaKey is perfection! This amazing product has help tremendously with hormonal imbalance. If you are considering this product do hesitate, I second guessed myself years ago and struggled with my weight, flashes, sleeplessness, etc. Don't overthink this, try it and I promise you will not regret it. I make sure I always have a 2nd bottle on deck to ensure I am consistent with no more hot flashes."
– Linda Y.

"Finally relief! My hot flashes have ceased and my brain fog is gone! I'm sleeping much better, thanks to ProgestaKey."
– Rosemary S.

" was experiencing extreme short cycles this last year and my mom recommended this lotion to me. She gave me one of her ProgestaKey lotions to try. Since starting it my cycles are exactly 28 days! And my PMS symptoms are gone and period cramps are diminished. Love this lotion and even recommended it to my doctor at my last appointment! She said she would try it!"
– Karyn G.

Recommended by Ann Louise Gittleman, PhD, CNS

Top Nutritionist & New York Times Bestselling Author

"When it comes to women's health, progesterone has been missing from conversation for far too long. While estrogen gets all the attention, it's progesterone that quietly safeguards your bones, brain, metabolism, and nervous system. And when it begins to slip away—as early as your mid-30s—you start to feel the cracks in your foundation.

That's why I formulated ProgestaKey: a clean, wild yam–based progesterone crème that restores what stress, age, and modern living have depleted. Just one pump delivers 20 mg of bioidentical progesterone—the same form your body naturally makes—along with other natural beneficial ingredients.

Time and again, I've seen women's lives transformed when their progesterone levels are replenished. Suddenly, they're sleeping deeply again, their moods are steadier, their energy returns, and their spark for life is reignited. Balance is possible—and ProgestaKey can help make it happen.

Why Buy from UNI KEY?

Our Quality Promise

At UNI KEY Health, we are committed to providing the highest quality supplements. Our products are manufactured in the USA at a Good Manufacturing Practices (GMP) and FDA-registered facility. Each batch undergoes rigorous testing for purity, potency, and heavy metals to ensure you receive only the best.

100% Satisfaction Guarantee

We stand behind every product we offer with our 90-Day Money-Back Guarantee. If you're not completely satisfied for any reason, simply call us at 1-800-888-4353 or email info@unikeyhealth.com, and we’ll make it right. 

We invite you to try UNI KEY Health products today—RISK FREE! 

Verified Customer Reviews

Customer Reviews

Based on 172 reviews
81%
(139)
8%
(13)
6%
(11)
2%
(4)
3%
(5)
R
Robbin G.

Loving it so far. Helping me with sleep and maybe calming too. Thank you. Appreciate your dedication to your products too.

A
Anonymous

ProgestaKey helps with insomnia and relaxation..

A
Anonymous

Love this product!

K
Kathleen M.

I have been using the progestakey for 28 years and I like it but also because my MD says to stay on it.

Thank you for your great review! We’re so glad to hear that ProgestaKey has been a trusted part of your routine for so many years. Thank you for choosing UNI KEY :)

K
Kerry C.

Great to manage hot flashes!

123

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